VDO Civil

April 4, 2008 - Before speaking to the 5th Clinical Conference on Cannabis Therapeutics in Pacific Grove, CA, Deputy Director of NORML Paul Armentano talks about new science on Cannabis (marijuana) and the Endo-Cannabinoid system being done in Europe, while American cancer patients, many with tragic cases of Glioma brain tumors, seek any news of an alternative therapy. Paul references the work of Dr. Manuel Guzman, Madrid, who has seen THC kill brain cancer cells while leaving surrounding tissue unharmed, demonstating the neuroprotectant properties of Cannabinoids. Then Paul is joined by Dr. David Bearman, of Galeta, CA, who tells of the fear that patients feel when encountering an cancer like Glioma. Paul has collected the latest research on medical Cannabis, available in a PDF or booklet at: http://norml.org We also talk about Cannabis in the treatment of ALS (Lou Gehrig's Disease) and the documentary I'm doing on Cathy Jordan, a medical marijuana patient who has survived ALS for 22 years now! View "Surviving ALS" in chapter releases: http://YouTube.com/SurvivingALS Cannabis Therapeutics Conference hosted by Patients Out of Time: http://MedicalCannabis.com

Histopathology Brainstem--Glioma

Glioma Research (click more for details) A review of the modern scientific literature reveals numerous preclinical studies and one pilot clinical study demonstrating cannabinoids' ability to act as antineoplastic agents, particularly on glioma cell lines. Writing in the September 1998 issue of the journal FEBS Letters, investigators at Madrid's Complutense University, School of Biology, first reported that delta-9-THC induced apoptosis (programmed cell death) in glioma cells in culture.[1] Investigators followed up their initial findings in 2000, reporting that the administration of both THC and the synthetic cannabinoid agonist WIN 55,212-2 "induced a considerable regression of malignant gliomas" in animals.[2] Researchers again confirmed cannabinoids' ability to inhibit tumor growth in animals in 2003.[3] That same year, Italian investigators at the University of Milan, Department of Pharmacology, Chemotherapy and Toxicology, reported that the non-psychoactive cannabinoid, cannabidiol (CBD), inhibited the growth of various human glioma cell lines in vivo and in vitro in a dose dependent manner. Writing in the November 2003 issue of the Journal of Pharmacology and Experimental Therapeutics Fast Forward, researchers concluded, "Non-psychoactive CBD ... produce[s] a significant anti-tumor activity both in vitro and in vivo, thus suggesting a possible application of CBD as an antineoplastic agent."[4] To see this text in full: http://www.norml.org/index.cfm?Group_ID=7008 _______________ The Author: For patients and their physicians, let this report serve as a primer for those who are considering using or recommending medicinal cannabis. For others, let this report serve as an introduction to the broad range of emerging clinical applications for cannabis and its various compounds. Paul Armentano Deputy Director NORML | NORML Foundation Washington, DC January 24, 2008 * The author would like to acknowledge Drs. Dale Gieringer, Gregory Carter, Steven Karch, and Mitch Earleywine, as well as NORML interns John Lucy, Christopher Rasmussen, and Rita Bowles, for providing research assistance for this report. The NORML Foundation would also like to acknowledge Dale Gieringer, Paul Kuhn, and Richard Wolfe for their financial contributions toward the publication of this report. ** Important and timely publications such as this are only made possible when concerned citizens become involved with NORML. For more information on joining NORML or making a donation, please visit: http://www.norml.org/join. Tax deductible donations in support of NORML's public education campaigns should be made payable to the NORML Foundation. http://norml.com/index.cfm?Group_ID=7002 _______________________________________ Prohibition: "Prohibition...goes beyond the bounds of reason in that it attempts to control a man's appetite by legislation and makes a crime out of things that are not crimes. A prohibition law strikes a blow at the very principles upon which our government was founded." -- Abraham Lincoln December 1840

Dr. Tim Cloughesy discusses malignant glioma, the type of brain cancer faced by Senator Ted Kennedy.

Tribute to all the girls who battled DIPG and have now sadly passed away. This type of cancer is so rare that these are the only girls that I am aware of who have gained their wings from DIPG. Please pray for their families and all of the others who are now dancing in heaven. DIPG has no cure and most children die within one year of diagnosis. This debilitating, heart wrenching disease slowly robs children of their motor functions resulting in partial paralysis, loss of voice, sight, hearing and finally an inability to eat and breathe. Please donate to DIPG causes and help us to find a cure. Visit http:///www.icouldbeyourchild.org http://www.prayersfrommaria.org www.justonemoreday.org To find out more about this type of tumor and to read most of these kids inspirational stories.

Pediatric Brain Cancer

Tribute to all the kids who are currently battling DIPG each and every day. This type of cancer is so rare that these are the only kids that I am aware of who are current survivors of DIPG. Please pray for their families and all of the others who are now free in heaven. DIPG has no cure and most children die within one year of diagnosis. This debilitating, heart wrenching disease slowly robs children of their motor functions resulting in partial paralysis, loss of voice, sight, hearing and finally an inability to eat and breathe. Please donate to DIPG causes and help us to find a cure. Visit http:///www.icouldbeyourchild.org http://www.prayersfrommaria.org www.justonemoreday.org To find out more about this type of tumor and to read most of these kids inspirational stories.

Non-adherent cell treated with metal colloid based agent to induce apoptosis.

Tribute to all the boys who battled DIPG and have now sadly passed away. This type of cancer is so rare that these are the only boys that I am aware of who have gained their wings from DIPG. Please pray for their families and all of the others who are now free in heaven. DIPG has no cure and most children die within one year of diagnosis. This debilitating, heart wrenching disease slowly robs children of their motor functions resulting in partial paralysis, loss of voice, sight, hearing and finally an inability to eat and breathe. Please donate to DIPG causes and help us to find a cure. Visit http:///www.icouldbeyourchild.org http://www.prayersfrommaria.org www.justonemoreday.org To find out more about this type of tumor and to read most of these kids inspirational stories.

video de una de las raras tokadas de glioma en su evento glioma fest 2

Treatment and prognosis for Sen. Edward Kennedy's malignant brain tumor largely depends on the size, type and location of the tumor, CBS station WBZ-TV in Boston reported. May 21 2008

Dance choreographed to a parody of 'My Sharona' for UNSW Medshow 2006 (The Phantom of the OR) This demo video was sent round to dancers to help them learn the steps! I like the air guitar :) Choreography: Anh

Glioma,sex machines,eolian,etc etc @ Kardo's tokin

2 scientists in Oklahoma are close to finding a cure for malignant glioma, the same kind of brain cancer that Sen. Ted Kennedy of Massachussetts was diagnosed with recently.

Local Immunotoerapy of Glioma

Glioma - Yo soy un chico rave (Live @ glioma fest 2)

Local Immunotoerapy of Glioma

Local Immunotoerapy of Glioma

CAT scan images of the tumor.

El changoleon y el martin calando instrumentos y echando cotorreo

Researchers have identified a 'switch' mechanism that could provide a vital breakthrough into efforts to combat brain cancer. Canada AM: Dr. Peter Forsyth, University of Calgary The invasive nature of cancers in general, and malignant gliomas in particular, is a major clinical problem rendering tumors incurable by conventional therapies. Using a novel invasive glioma mouse model established by serial in vivo selection, we identified the p75 neurotrophin receptor (p75NTR) as a critical regulator of glioma invasion. Through a series of functional, biochemical, and clinical studies, we found that p75NTR dramatically enhanced migration and invasion of genetically distinct glioma and frequently exhibited robust expression in highly invasive glioblastoma patient specimens. Moreover, we found that p75NTR-mediated invasion was neurotrophin dependent, resulting in the activation of downstream pathways and producing striking cytoskeletal changes of the invading cells. These results provide the first evidence for p75NTR as a major contributor to the highly invasive nature of malignant gliomas and identify a novel therapeutic target.

niversity Hospitals Neurological Institute will host a live webcast to demonstrate the removal of a brain tumor that doctors believe is causing epileptic seizures in a middle-aged man. An MRI showed what appears to be a glioma (tumor) near a part of the brain that controls muscle movement, called the motor strip. Studies have shown that complete removal can cure the seizures and improve quality of life and survival, but this is difficult to do with conventional technology without harming the surrounding normal brain because it's difficult to determine where tumor ends and normal brain begins.

Madrid, Spain: Compounds in marijuana inhibit malignant brain tumor growth in animals, and may provide a potential therapy for human glioma patients, according to a clinical review appearing in the September issue of Neuropharmacology. "Current therapeutic strategies for the treatment of [gliomas] are usually ineffective or just palliative," researchers from the Department of Biochemistry and Molecular Biology at Madrid's Complutense University wrote. "During the last few years, several studies have shown that cannabinoids ... slow the growth of different types of tumours, including gliomas, in laboratory animals. Cannabinoids induce apoptosis (programmed cell death) of glioma cells [in vitro.] In addition, cannabinoid treatment inhibits angiogenesis (growth) of gliomas in vivo. Remarkably, cannabinoids kill glioma cells selectively and can protect non-transformed glial cells from death. These and other findings reviewed here might set the basis for a potential use of cannabinoids in the management of gliomas." Last year, a clinical review in the journal Nature Reviews Cancer made similar recommendations, noting that cannabinoids possess a "favorable drug safety profile" and have shown in clinical trials to inhibit various forms of cancerous tumors, including gliomas, lung carcinoma, breast cancer, skin cancer, thyroid cancer, lymphoma, and prostate cancer. For more information, please contact Paul Armentano, NORML Senior Policy Analyst, at (202) 483-5500. Abstracts of the review are available online at: http://else.hebis.de/cgi-bin/sciserv.pl?collection=journals&journal=00283908 The author For patients and their physicians, let this report serve as a primer for those who are considering using or recommending medicinal cannabis. For others, let this report serve as an introduction to the broad range of emerging clinical applications for cannabis and its various compounds. Paul Armentano Deputy Director NORML | NORML Foundation Washington, DC January 24, 2008 * The author would like to acknowledge Drs. Dale Gieringer, Gregory Carter, Steven Karch, and Mitch Earleywine, as well as NORML interns John Lucy, Christopher Rasmussen, and Rita Bowles, for providing research assistance for this report. The NORML Foundation would also like to acknowledge Dale Gieringer, Paul Kuhn, and Richard Wolfe for their financial contributions toward the publication of this report. ** Important and timely publications such as this are only made possible when concerned citizens become involved with NORML. For more information on joining NORML or making a donation, please visit: http://www.norml.org/join. Tax deductible donations in support of NORML's public education campaigns should be made payable to the NORML Foundation. http://norml.com/index.cfm?Group_ID=7002 _______________________________________ "Prohibition...goes beyond the bounds of reason in that it attempts to control a man's appetite by legislation and makes a crime out of things that are not crimes. A prohibition law strikes a blow at the very principles upon which our government was founded." -- Abraham Lincoln December 1840 _____________________________________ background music, http://www.soundsnap.com

November 2006 - A vaccine for treating a recurrent cancer of the central nervous system that occurs primarily in the brain, known as glioma, has shown promising results in preliminary data from a clinical trial at UCSF Medical Center. Findings from the first group of six patients in the study, being conducted at the UCSF Brain Tumor Research Center, showed that vitespen (trademarked as Oncophage), a vaccine made from the patient's own tumor, was associated with tumor-specific immune response in patients with recurrent, high-grade glioma. More info at http://www.glioblastoma.it

Gliadel® Wafer (polifeprosan 20 with carmustine implant) is indicated in newly diagnosed patients with high-grade malignant glioma as an adjunct to surgery and radiation. Gliadel is also indicated in recurrent glioblastoma multiforme patients as an adjunct to surgery. Gliadel provides localized delivery of chemotherapy directly to the site of the tumor and is the only FDA approved brain cancer treatment capable of doing so. More info at http://www.glioblastoma.it